Sighting in bullseye guns

How do you guys sight in your guns. 
My is dead on off a rest but everything is right when shooting bullseye. 
Do you adjust your guns from calling your shots one handed ??

Yes, call the shot and adjust quickly. I bench rest my pistols after changing a dot or changing a load but I know I will have to change the sights when I bring it up one handed. The 22s don't seem to change much but the centerfires all move some. Be confident in your call and adjust.

Len

Thanks I am going to give that a try I always relied on the settings off the bench. I just shot a practice 900 and had a 27x and am a little  afraid  to change my settings. Everything that wasn't a x was to the right

you can zero off a rest if it supports only your shooting arm at the height and stance you normally shoot from, best to do this then check with normal stance at 25 yds, then you can figure aprox 3-5 clicks up will get you in the 10 ring at 50yd.

Oh, yeah, it's not the same for me!

.45 ammo testing, 2-handed over a rest and zeroed to the X because I love to see them in the black...well they hit in the middle of the 6-ring at 12:00 at 50 yards when I go one-handed.

Trust your call, but be honest with yourself first and all along the way. Pay attention to your front sight or the dot AND to how the recoil lifts it up AND pay attention to the grip too.

I like to use rest when setting up new gun then shoot normal bullseye stance at 25 yards and shoot slow fire ten shots take all the time you need to try and make every shot a X then look at group and adjust after that I shoot a 900 and look at the 90 shot group and may be adjust another klick or two as needed.

O from a sold bench and then tweek adj off hand

For me, if the 50 yard slow fire single hand groups are centered, then I shoot the gun from a two-handed grip on a rest, the group will be about 2" low and 1" right, for the .45, shooting 185 gr bullets.  Not hardly any difference for the .22 at 50 yard due to less muzzle movement during recoil.  I'm right handed.

Point is that the grip will affect the 50 yard group location.  Just find out what the gun needs from a rest to shoot zero in a match and adjust to there as a start when changing sights, etc. 

Joe